Review
Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy
In: Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands [Internet]. Cham (CH): Springer; 2018. Chapter 6.
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Affiliations
- PMID: 31314355
- Bookshelf ID: NBK543772
- DOI: 10.1007/978-3-319-65639-7_6
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Review
Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy
Excerpt
The antimicrobial activity of metal ions, especially silver ions, has been known since ancient times. Consequently, finding an accessible, cheap and efficient carrier of metal ions remains an important challenge in molecular biology. The supramolecular system presented in this chapter consists of a mixture of Congo red and Titan yellow molecules forming a supramolecular ligand which is a potent complexing agent of silver ions. Delivery of ions in complex with supramolecular dye is advantageous due to the reduced toxicity. In addition, the use of Congo red provides selective action and – thanks to increased solubility – facilitates efficient dispersion of the carrier dye and excretion from the organism.
Copyright 2018, The Author(s).
Sections
- 6.1. Introduction
- 6.2. Silver Complexes with TY in the Supramolecular CR System
- 6.3. Antimicrobial and Antifungal Activity of Silver Ion Complexes with Titan Yellow (TY/Ag+) and TY/Ag+ Complexes with Congo Red (CR /TY/Ag+)
- 6.4. Determination of the Effect of TY/Ag+ and CR /TY/Ag+ on Antibiotic Activity on Selected Standard and Clinical Bacterial Strains
- 6.5. Cytotoxicity Analysis of the TY/Ag+ Complex
- 6.6. Summary
- Acknowledgements
- References
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