Mouse Watch: A Cautionary Tale
- PMID: 31315029
- DOI: 10.1016/j.immuni.2019.06.019
Mouse Watch: A Cautionary Tale
Abstract
In this issue of Immunity, Chisolm et al. (2019) issue a "three-alarm fire" warning to the immunology research community of unexpectedly widespread genetic variation in widely used congenic mouse strains and provide a simple method to identify such a variation through a re-analysis of existing RNA-seq and ChIP-seq datasets.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.Immunity. 2019 Jul 16;51(1):155-168.e5. doi: 10.1016/j.immuni.2019.05.006. Epub 2019 Jun 24. Immunity. 2019. PMID: 31248780 Free PMC article.
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