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. 2021 May;34(10):1679-1682.
doi: 10.1080/14767058.2019.1645828. Epub 2019 Jul 29.

Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control analysis

Domenico Giordano  1 , Valeria Cernaro  2 , Mariagrazia Scilipoti  3 , Sonia Cosentino  4 , Ramona Inferrera  3 , Jlenia Fresta  3 , Michele Andreucci  4 , Giovanni Conti  3 , Michele Buemi  2 , Rosario D'Anna  1 , Giuseppe Coppolino  4
Affiliations

Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control analysis

Domenico Giordano et al. J Matern Fetal Neonatal Med. 2021 May.

Abstract

Purpose: To evaluate the relation between CD34+ cells count in maternal blood and potential development of fetal congenital renal abnormalities.

Materials and methods: We enrolled 16 women that gave birth to newborns carrying congenital renal malformations over a 3-year period and 48 women with uncomplicated pregnancies (controls) in a 1:3 ratio (three controls per case).

Results: CD34+ cells in the maternal peripheral blood were significantly lower in the group of women who gave birth to newborns carrying congenital renal malformations compared to the controls (p < .0001).

Conclusions: CD34+ cells in maternal blood could be validated as a potential marker to predict the development of possible kidney malformations.

Keywords: CD34+; fetal kidney malformations; first trimester; hematopoietic stem cells; maternal.

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