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. 2019 Jul 17;18(1):155.
doi: 10.1186/s12944-019-1091-7.

Epidemiological characteristics and risk factors of T2DM in Chinese premenopausal and postmenopausal women

Qingjun Li  1 , Xiaoqing Wang  1 , Yaojun Ni  2 , Hairong Hao  1 , Ziyu Liu  1 , Surong Wen  1 , Xiaojuan Shao  1 , Xiaojuan Wu  1 , Weinan Yu  3 , Wen Hu  4
Affiliations

Epidemiological characteristics and risk factors of T2DM in Chinese premenopausal and postmenopausal women

Qingjun Li et al. Lipids Health Dis. .

Abstract

Objective: This study was to analyse the prevalence of type 2 diabetes mellitus (T2DM) in premenopausal and postmenopausal women.

Methods: A total of 3227 women met the requirements from June to December in 2014, including 207 cases of premenopausal women and 3020 cases of postmenopausal women. The prevalence of T2DM and the associated risk factors in the two groups were analysed.

Results: The prevalence of premenopausal women with T2DM was 12.1%, while the prevalence in postmenopausal women was 19.4% (P < 0.05). Total serum protein (TP) (OR = 1.164 95% CI = 1.023-1.324) (P = 0.021) is a major risk factor for premenopausal women with T2DM. The prevalence of T2DM increased with the increase in TP. In postmenopausal groups, the prevalence of T2DM was associated with age (OR = 1.037 95% CI = 1.024-1.051) (P < 0.001), BMI (OR = 1.076 95% CI = 1.044-1.109) (P < 0.001), blood pressure (OR = 1.521 95% CI = 1.234-1.875) (P < 0.001), triglycerides (TG) (OR = 1.106 95% CI = 1.027-1.190) (P = 0.008), blood urea nitrogen (BUN) (OR = 1.065 95% CI = 1.004-1.129) (P = 0.036), alanine aminotransferase (ALT) (OR = 1.009 95% CI = 1.003-1.016) (P = 0.004) and TP (OR = 1.031 95% CI = 1.005-1.057) (P = 0.018).

Conclusions: Postmenopausal women have a higher rate of type 2 diabetes than premenopausal women. TP is a major risk factor for premenopausal women with T2DM. TP, ALT, and BUN are postmenopausal risk factors in addition to traditional risk factors such as obesity, lipidaemia and blood pressure. We should monitor risk factors and take early prevention and intervention measures to reduce the prevalence of diabetes and improve the quality of life of postmenopausal women.

Trial registration: ChiCTR, ChiCTR-TRC-14005029. Registered 29 July 2014, http://www.chictr.org.cn/showproj.aspx?proj=4545.

Keywords: Menopausal; Prevalence; Risk factors; T2DM.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Multiple logistic regression analyses of the odds ratio for T2DM in the premenopausal and postmenopausal groups. BMI body mass index; WC waist circumference; SBP systolic blood pressure; DBP diastolic blood pressure; TG triglycerides; BUN blood urea nitrogen; TG triglycerides; UA uric acid; BUN blood urea nitrogen; TP total protein
Fig. 2
Fig. 2
Dose-response between TP and T2DM in the total population. OR: odds ratio; UCI: Upper confidence interval; LCI:Lower confidence interval
See this image and copyright information in PMC

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