Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

Diego Salas-Benito^{1

2}, Ignacio Melero^{2

3

4}, Mariano Ponz-Sarvise^{5

4

6}

Affiliations

¹ Department of Medical Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
² Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
³ Department of Immunology and Immunotherapy, Clinica Universidad de Navarra, Pamplona, Spain.
⁴ IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
⁵ Department of Medical Oncology, Clinica Universidad de Navarra, Pamplona, Spain. mponz@unav.es.
⁶ Program in Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

PMID: 31315885
DOI: 10.1158/1078-0432.CCR-19-1753

Comment

Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

Diego Salas-Benito et al. Clin Cancer Res. 2019.

. 2019 Sep 15;25(18):5435-5437.

doi: 10.1158/1078-0432.CCR-19-1753. Epub 2019 Jul 17.

Authors

Diego Salas-Benito^{1

2}, Ignacio Melero^{2

3

4}, Mariano Ponz-Sarvise^{5

4

6}

Affiliations

¹ Department of Medical Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
² Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
³ Department of Immunology and Immunotherapy, Clinica Universidad de Navarra, Pamplona, Spain.
⁴ IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
⁵ Department of Medical Oncology, Clinica Universidad de Navarra, Pamplona, Spain. mponz@unav.es.
⁶ Program in Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

PMID: 31315885
DOI: 10.1158/1078-0432.CCR-19-1753

Abstract

No immunotherapy strategy is yet offering consistent results against pancreatic ductal adenocarcinoma. A randomized clinical trial testing repeated immunization with a Listeria monocytogenes-based vaccine encoding for mesothelin in combination with a GM-CSF-transfected allogeneic pancreatic cell vaccine reports no survival benefit for the vaccinated patients.See related article by Le et al., p. 5493.

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Comment in

Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study).
Le DT, Picozzi VJ, Ko AH, Wainberg ZA, Kindler H, Wang-Gillam A, Oberstein P, Morse MA, Zeh HJ 3rd, Weekes C, Reid T, Borazanci E, Crocenzi T, LoConte NK, Musher B, Laheru D, Murphy A, Whiting C, Nair N, Enstrom A, Ferber S, Brockstedt DG, Jaffee EM. Le DT, et al. Clin Cancer Res. 2019 Sep 15;25(18):5493-5502. doi: 10.1158/1078-0432.CCR-18-2992. Epub 2019 May 24. Clin Cancer Res. 2019. PMID: 31126960 Free PMC article.

Comment on

Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study).
Le DT, Picozzi VJ, Ko AH, Wainberg ZA, Kindler H, Wang-Gillam A, Oberstein P, Morse MA, Zeh HJ 3rd, Weekes C, Reid T, Borazanci E, Crocenzi T, LoConte NK, Musher B, Laheru D, Murphy A, Whiting C, Nair N, Enstrom A, Ferber S, Brockstedt DG, Jaffee EM. Le DT, et al. Clin Cancer Res. 2019 Sep 15;25(18):5493-5502. doi: 10.1158/1078-0432.CCR-18-2992. Epub 2019 May 24. Clin Cancer Res. 2019. PMID: 31126960 Free PMC article.

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Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

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Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

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