Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep 24;57(10):e00834-19.
doi: 10.1128/JCM.00834-19. Print 2019 Oct.

Antimycobacterial Susceptibility Testing of Nontuberculous Mycobacteria

Affiliations
Review

Antimycobacterial Susceptibility Testing of Nontuberculous Mycobacteria

Barbara A Brown-Elliott et al. J Clin Microbiol. .

Abstract

Recommendations for first-line and second-line drug testing and organism group, specific methodologies, and reporting recommendations have been addressed by the Clinical and Laboratory Standards Institute (CLSI) and are important in the selection of appropriate antimicrobial treatment regimens for nontuberculous mycobacteria (NTM) disease. This review also includes recent information on new antimicrobials proposed for the treatment of NTM but not yet addressed by the CLSI and molecular (gene sequencing) methods associated with the detection of antimicrobial resistance of two major therapeutic antimicrobials, clarithromycin and amikacin.

Keywords: mycobacteria; nontuberculous mycobacteria; susceptibility.

PubMed Disclaimer

References

    1. Clinical and Laboratory Standards Institute. 2011. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; approved standard, 2nd ed CLSI document M24-A2 Clinical and Laboratory Standards Institute, Wayne, PA. - PubMed
    1. Clinical and Laboratory Standards Institute. 2018. Susceptibility testing of mycobacteria, Nocardia spp., and other aerobic actinomycetes, 3rd ed, CLSI standard document M24 Clinical and Laboratory Standards Institute, Wayne, PA. - PubMed
    1. Clinical and Laboratory Standards Institute. 2018. Performance standards for susceptibility testing of mycobacteria, Nocardia spp., and other aerobic actinomycetes, 1st ed CLSI document M62 Clinical and Laboratory Standards Institute, Wayne, PA. - PubMed
    1. Clinical and Laboratory Standards Institute. 2018. Laboratory detection and identification of mycobacteria. CLSI guideline M48 Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K. 2007. An official ATS/IDSA statement: diagnosis, treatment and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175:367–416. doi:10.1164/rccm.200604-571ST. - DOI - PubMed

MeSH terms

Substances