Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 17;11(501):eaay1018.
doi: 10.1126/scitranslmed.aay1018.

Diverse compositions and functions of chromatin remodeling machines in cancer

Cigall Kadoch  1   2
Affiliations
Review

Diverse compositions and functions of chromatin remodeling machines in cancer

Cigall Kadoch. Sci Transl Med. .

Abstract

Human cancer genetics power biochemical and functional interrogation of chromatin remodeling complexes, informing therapeutic opportunities.

PubMed Disclaimer

Conflict of interest statement

Competing interests: C.K. is the scientific founder, fiduciary board of directors member, scientific advisory board member, consultant, and shareholder of Foghorn Therapeutics Inc. (Cambridge, MA).

Figures

Fig. 1.
Fig. 1.. mSWI/SNF ATP-dependent chromatin remodeling complexes: Unmasking diverse oncogenic mechanisms.
Summary of key studies to define biochemical properties, chromatin interactions, structure, and gene regulatory functions of mSWI/SNF chromatin remodeling complexes. The three mSWI/SNF family complexes (cBAF, PBAF, and ncBAF) are drawn as one for simplicity.
See this image and copyright information in PMC

References

    1. Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng P. Kwok-Shing, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang W-W, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, MC3 Working Group, Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L, Comprehensive characterization of cancer driver genes and mutations. Cell 174, 1034–1035 (2018). - PMC - PubMed
    1. Kadoch C, Crabtree GR, Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 153, 71–85 (2013). - PMC - PubMed
    1. Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C, SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat. Genet 49, 1613–1623 (2017). - PMC - PubMed
    1. McBride MJ, Pulice JL, Beird HC, Ingram DR, D’Avino AR, Shern JF, Charville GW, Hornick JL, Nakayama RT, Garcia-Rivera EM, Araujo DM, Wang W-L, Tsai J-W, Yeagley M, Wagner AJ, Futreal PA, Khan J, Lazar AJ, Kadoch C, The SS18-SSX fusion oncoprotein hijacks BAF complex targeting and function to drive synovial sarcoma. Cancer Cell 33, 1128–1141.e7 (2018). - PMC - PubMed
    1. Pan J, Meyers RM, Michel BC, Mashtalir N, Sizemore AE, Wells JN, Cassel SH, Vazquez F, Weir BA, Hahn WC, Marsh JA, Tsherniak A, Kadoch C, Interrogation of mammalian protein complex structure, function, and membership using genome-scale fitness screens. Cell Syst. 6, 555–568.e7 (2018). - PMC - PubMed

LinkOut - more resources