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. 2019;23(2):81-86.
doi: 10.5114/wo.2019.85878. Epub 2019 Jun 13.

Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia

Przemysław M Krzaczek  1 , Małgorzata Mitura-Lesiuk  2 , Joanna Zawitkowska  2 , Beata Petkowicz  1 , Barbara Wilczyńska  3 , Katarzyna Drabko  2
Affiliations

Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia

Przemysław M Krzaczek et al. Contemp Oncol (Pozn). 2019.

Abstract

Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF-α and IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.

Keywords: acute lymphoblastic leukemia; cytokines; oral lesions.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Serum concentration of TNF-α in analyzed groups
Fig. 2
Fig. 2
Saliva concentration of TNF-α in analyzed groups
Fig. 3
Fig. 3
Serum concentration of IL-10 in analyzed groups
Fig. 4
Fig. 4
Saliva concentration of IL-10 in analyzed groups
Fig. 5
Fig. 5
Average subjecitve complaines according to Visual Analogue Scale (VAS) in analyzed groups
See this image and copyright information in PMC

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