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. 2019 Jun 17:2019:2403718.
doi: 10.1155/2019/2403718. eCollection 2019.

Antioxidant Potential, Phytochemicals Composition, and Metal Contents of Datura alba

Waliullah Khan  1 , Sidra Subhan  1 , Dilawar Farhan Shams  2 , Sahib Gul Afridi  3 , Riaz Ullah  4 , Abdelaaty A Shahat  4   5   6 , Ali S Alqahtani  4   6
Affiliations

Antioxidant Potential, Phytochemicals Composition, and Metal Contents of Datura alba

Waliullah Khan et al. Biomed Res Int. .

Abstract

This study investigated the phytochemical characteristics and antioxidant activity in leaves, roots, stem, flower, and seed parts of Datura alba (D. alba). The study also assessed the heavy metal (Cr, Mn, Zn, and Cu) accumulation in each part of the plant. Among the phytochemicals, alkaloids were found only in leaves while tannins, flavonoids, and phenols were present in all parts of the plant. For antioxidant activity, free radical scavenging assay for 2,2-diphenyl-1-picrylhydrazyl (DPPH) was performed using ascorbic acid as the standard. Higher activity was shown by stem extract in methanol and leaf extract in n-hexane, ethyl acetate, and chloroform. Furthermore, all the target heavy metals were detected in all plant sections with the highest concentration of Zn in leaves and Cu in stem, root, flower, and seed. Due to stronger antioxidant potential and phytochemical composition, D. alba could prove as valuable prospect in pharmaceutical formulations by taking part in the antioxidant defense system against generation of free radicals.

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Figures

Figure 1
Figure 1
Phytochemicals content in different parts of D. alba.
Figure 2
Figure 2
Antioxidant activity of ascorbic acid.
Figure 3
Figure 3
Antioxidant activity of methanol extracts.
Figure 4
Figure 4
Antioxidant activity of n-hexane extracts.
Figure 5
Figure 5
Antioxidant activity of ethyl acetate extracts.
Figure 6
Figure 6
Antioxidant activities of chloroform extracts.
Figure 7
Figure 7
The IC50 values for leaf, seed, stem, and root extracts in methanol, n-hexane, ethyl acetate, and chloroform.
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