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. 1988 May 11;16(9):4111-20.
doi: 10.1093/nar/16.9.4111.

Codon preference reflects mistranslational constraints: a proposal

D T McPherson  1
Affiliations
Free PMC article

Codon preference reflects mistranslational constraints: a proposal

D T McPherson. Nucleic Acids Res. .
Free PMC article

Abstract

Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.

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