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Review
. 2020 Jan;72(1):170-177.
doi: 10.1002/iub.2130. Epub 2019 Jul 17.

GATA-3 in T-cell lymphoproliferative disorders

Carlos Murga-Zamalloa  1 , Ryan A Wilcox  1
Affiliations
Review

GATA-3 in T-cell lymphoproliferative disorders

Carlos Murga-Zamalloa et al. IUBMB Life. 2020 Jan.

Abstract

GATA-3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA-3 in the pathogenesis of molecularly, genetically, and clinically distinct T-cell lymphoproliferative disorders, but also have significant diagnostic, prognostic, and therapeutic implications.

Keywords: CTCL; GATA-3; PTCL; T-ALL.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no potential conflict of interest.

References

    1. Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A, Flowers CR. 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA Cancer J Clin. 2016;66: 443–459. - PubMed
    1. Laurent C, Baron M, Amara N, et al. Impact of expert pathologic review of lymphoma diagnosis: Study of patients from the French Lymphopath Network. J Clin Oncol. 2017;35:2008–2017. - PubMed
    1. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: Pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124–4130. - PubMed
    1. Mak V, Hamm J, Chhanabhai M, et al. Survival of patients with peripheral T-cell lymphoma after first relapse or progression: Spectrum of disease and rare long-term survivors. J Clin Oncol. 2013;31:1970–1976. - PubMed
    1. Briski R, Feldman AL, Bailey NG, et al. The role of front-line anthracycline-containing chemotherapy regimens in peripheral T-cell lymphomas. Blood Cancer J. 2014;4:e214. - PMC - PubMed

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