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Observational Study
. 2020 Jun 1;95(7):1249-1256.
doi: 10.1002/ccd.28396. Epub 2019 Jul 18.

Short-term safety and long-term benefits of stent postdilation after primary percutaneous coronary intervention: Results of a cohort study

Nasser Saadat  1 , Seyedmohammad Saadatagah  1 , Arash Aghajani Nargesi  2 , Mohammad Alidoosti  1 , Hamidreza Poorhosseini  1 , Alireza Amirzadegan  1 , Reza Lashkari  1 , Seyedeh Hamideh Mortazavi  1 , Arash Jalali  1 , Saeed Ghodsi  1 , Mojtaba Salarifar  1
Affiliations
Observational Study

Short-term safety and long-term benefits of stent postdilation after primary percutaneous coronary intervention: Results of a cohort study

Nasser Saadat et al. Catheter Cardiovasc Interv. .

Abstract

Aim: Achieving the optimal apposition of coronary stents during percutaneous coronary intervention is not always feasible. The risks and benefits of stent postdilation in primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI) have remained controversial. We sought to evaluate the immediate angiographic and long-term outcomes in patients with and without stent postdilation.

Methods: A cohort of patients (n = 1,224) with STEMI, treated with PPCI (n = 500 postdilated; n = 724 controls), were studied. The flow grade, the myocardial blush grade, and the frame count were considered angiographic outcomes. The clinical outcomes were major adverse cardiovascular events (MACE)-comprising cardiac death, nonfatal MI, and repeat revascularization-and the device-oriented composite endpoint (DOCE)-consisting of cardiac death, target lesion revascularization, and target vessel revascularization.

Results: The flow and myocardial blush grades were not different between the two groups, and the frame count was significantly lower in the postdilation group (15.7 ± 8.4 vs. 17 ± 10.4; p < .05). The patients were followed up for 348 ± 399 days. DOCE (2.2% vs. 5.8%) and cardiac mortality (1.2% vs. 3.2%) were lower in the postdilation group. In the fully adjusted propensity score-matched analysis, postdilation was associated with decreased DOCE (HR = 0.40 [0.18-0.87], p = .021).

Conclusions: Selective postdilation improved some angiographic and clinical outcomes and could not be discouraged in PPCI on patients with STEMI.

Keywords: ST-elevation myocardial infarction; coronary artery disease; myocardial reperfusion injury; primary PCI; stent postdilation; stenting technique.

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