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. 2019 Dec;34(12):2152-2157.
doi: 10.1111/jgh.14787. Epub 2019 Aug 15.

Endoscopic closure of large colonic perforations with a novel endoscopic clip device: An animal study (with videos)

Zhi-Jie Wang  1   2 , Shi-Yu Li  2 , Yan-Hui Zhang  2 , Yan Chen  2 , Ping-Ping Zhang  2 , Zhao-Shen Li  2 , Yu Bai  2 , Dong Wang  1   2
Affiliations

Endoscopic closure of large colonic perforations with a novel endoscopic clip device: An animal study (with videos)

Zhi-Jie Wang et al. J Gastroenterol Hepatol. 2019 Dec.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] J Gastroenterol Hepatol. 2020 Jun;35(6):1088. doi: 10.1111/jgh.15074. J Gastroenterol Hepatol. 2020. PMID: 32537753 No abstract available.

Abstract

Background and aim: An endoscopic clip device was newly designed to accomplish the closure of large gastrointestinal defects. The aim of this study was to determine the feasibility and efficacy of this device in an ex vivo experimental setting.

Methods: This prospective study was conducted in porcine colons (n = 5). A large (3-4 cm) linear full-thickness incision was created using a scalpel externally. The device was used for endoscopic closure. The procedure time, number of clips, and success rate of closure were determined.

Results: Ten defects were created in five porcine colons (two incisions in each specimen). Successful closure was achieved in all defects. The mean procedure time was 24.30 ± 4.42 min, the mean leak pressure is 28.30 ± 9.49 mmHg, and the mean number of additional conventional hemostatic clips used was 5.10 ± 0.99.

Conclusions: The results indicated that this clip achieved the convenient and reliable closure of large defects in the colon wall in an ex vivo porcine model and seems to be a promising option for closing large gastrointestinal perforations.

Keywords: GI defect; closure; colon; endoscopic clip; iatrogenic perforation.

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