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Review
. 2019 Jul 17;11(7):1624.
doi: 10.3390/nu11071624.

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Danja J Den Hartogh  1   2 , Evangelia Tsiani  3   4
Affiliations
Review

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Danja J Den Hartogh et al. Nutrients. .

Abstract

Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol.

Keywords: fibroblasts; glomerulosclerosis; kidney disease; mesangial cells; renal cancer; renal epithelial cells; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The structure of the glomerulus and nephron.
Figure 2
Figure 2
Effects of resveratrol on cellular signaling molecules. The figure was created based on the data of the studies [66,76,80,81,85,91,95,101,102]. AKT: protein kinase B; PDK: pyruvate dehydrogenase kinase; PIP3: phosphatidylinositol-3,4,5-triphosphate; PIP2: phosphatidylinositol 4,5-bisphosphate; ERK: extracellular signal-regulated kinase; PI3K: phosphoinositide 3-kinase; Grb: growth factor receptor-bound protein; PDGF: Platelet-derived growth factor; EMT: extracellular matrix transition; JNK: c-Jun N-terminal kinase; AMPK: AMP-activated protein kinase; SIRT: sirtuin; PGC: Peroxisome proliferator-activated receptor gamma coactivator; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; TGF-β: transforming growth factor beta.
See this image and copyright information in PMC

References

    1. Vart P., Grams M.E. Measuring and assessing kidney function. Semin. Nephrol. 2016;36:262–272. doi: 10.1016/j.semnephrol.2016.05.003. - DOI - PubMed
    1. Pollak M.R., Quaggin S.E., Hoenig M.P., Dworkin L.D. The glomerulus: The sphere of influence. Clin. J. Am. Soc. Nephrol. 2014;9:1461–1469. doi: 10.2215/CJN.09400913. - DOI - PMC - PubMed
    1. Mitrakou A. Kidney: Its impact on glucose homeostasis and hormonal regulation. Diabetes Res. Clin. Pr. 2011;93:S66–S72. doi: 10.1016/S0168-8227(11)70016-X. - DOI - PubMed
    1. Dalal R., Sehdev J.S. StatPearls. StatPearls Publishing; Treasure Island, FL, USA: 2018. Physiology, renal, blood flow and filtration. - PubMed
    1. Kurtz S.B. Renal Function: Mechanisms Preserving Fluid and Solute Balance in Health. Mayo Clin. Proc. 1984;59:210. doi: 10.1016/S0025-6196(12)60780-0. - DOI

MeSH terms