Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2019 Jul 18;19(1):191.
doi: 10.1186/s12877-019-1204-1.

A multicenter cohort study to investigate the factors associated with functional autonomy change in patients with cognitive complaint or neurocognitive disorders: the MEMORA study protocol

Virginie Dauphinot  1   2   3 , Claire Moutet  4   5 , Isabelle Rouch  4   5   6 , Mathieu Verdurand  4   5 , Christelle Mouchoux  5   7   8 , Floriane Delphin-Combe  4   5 , Sylvain Gaujard  4   5 , Pierre Krolak-Salmon  4   5   7   8 ; MEMORA group
Collaborators, Affiliations
Clinical Trial

A multicenter cohort study to investigate the factors associated with functional autonomy change in patients with cognitive complaint or neurocognitive disorders: the MEMORA study protocol

Virginie Dauphinot et al. BMC Geriatr. .

Abstract

Background: The identification of factors associated with functional impairment, in particular those which are potentially modifiable, may help to delay the advanced stages of functional dependence in patients with neurocognitive disorders such as Alzheimer's disease and related disorders. The objectives of the MEMORA cohort are to investigate the factors associated, first with functional autonomy change over time, and secondarily with the cognitive performance and behavioral disorders changes over time.

Methods: The MEMORA study is a multicenter prospective cohort study carried out throughout the patient's care pathway, in Memory centers of Lyon (France). The study will include 6780 patients at all stages of memory disorders in 6 years. The follow-up for each patient is planned for 3 years. The main outcome is the functional autonomy level change as assessed by the instrumental abilities of daily living (IADL) score. Patient characteristics include sociodemographic and clinical features, neuropsychological performance, pharmaceutical and non-pharmaceutical therapy.

Discussion: This study conducted in a context of routine care may help to identify the factors associated with functional impairment related to progressive neurocognitive disorders. Subsequently, interventions on potentially modifiable factors could be proposed to the patients to improve their management and delay functional dependence.

Trial registration: NCT02302482 , registered 27 November 2014.

Keywords: Activity of daily living; Longitudinal study; Memory; Neurocognitive disorders.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer’s disease. Lancet. 2011;377:1019–1031. doi: 10.1016/S0140-6736(10)61349-9. - DOI - PubMed
    1. Tschanz JT, Corcoran C, Schwartz S, et al. Progression of cognitive, functional and neuropsychiatric symptom domains in a population cohort with Alzheimer’s dementia the Cache County dementia progression study. Am J Geriatr Psychiatry. 2011;19:532–542. doi: 10.1097/JGP.0b013e3181faec23. - DOI - PMC - PubMed
    1. Toot S, Swinson T, Devine M, Challis D, Orrel M. Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis. Int Psychogeriatr. 2017;29:195–208. doi: 10.1017/S1041610216001654. - DOI - PubMed
    1. Lipnicki DM, Crawford J, Kochan NA, et al. Risk factors for mild cognitive impairment, dementia and mortality: the Sydney memory and ageing study. J Am Med Dir Assoc. 2017;18:388–95. - PubMed
    1. Abellan van Kan G, Rolland Y, Nourhashémi F, Coley N, Andrieu S, Vellas B. Cardiovascular disease risk factors and progression of Alzheimer’s disease. Dement Geriatr Cogn Disord. 2009;27:240–246. doi: 10.1159/000203365. - DOI - PubMed

Publication types

Associated data