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Review
. 2021 Mar;268(3):796-809.
doi: 10.1007/s00415-019-09463-1. Epub 2019 Jul 18.

Language impairment in progressive supranuclear palsy and corticobasal syndrome

Katie A Peterson  1 , Karalyn Patterson  2 , James B Rowe  2
Affiliations
Review

Language impairment in progressive supranuclear palsy and corticobasal syndrome

Katie A Peterson et al. J Neurol. 2021 Mar.

Abstract

Although commonly known as movement disorders, progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) may present with changes in speech and language alongside or even before motor symptoms. The differential diagnosis of these two disorders can be challenging, especially in the early stages. Here we review their impact on speech and language. We discuss the neurobiological and clinical-phenomenological overlap of PSP and CBS with each other, and with other disorders including non-fluent agrammatic primary progressive aphasia and primary progressive apraxia of speech. Because language impairment is often an early and persistent problem in CBS and PSP, there is a need for improved methods for language screening in primary and secondary care, and more detailed language assessments in tertiary healthcare settings. Improved language assessment may aid differential diagnosis as well as inform clinical management decisions.

Keywords: Corticobasal syndrome; Language; Progressive supranuclear palsy.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Knibb JA, Xuereb JH, Patterson K, Hodges JR. Clinical and pathological characterization of progressive aphasia. Ann Neurol. 2006;59:156–165. doi: 10.1002/ana.20700. - DOI - PubMed
    1. Nestor PJ, Graham NL, Fryer TD, et al. Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain. 2003;126:2406–2418. doi: 10.1093/brain/awg240. - DOI - PubMed
    1. Cope TE, Sohoglu E, Sedley W, et al. Evidence for causal top-down frontal contributions to predictive processes in speech perception. Nat Commun. 2017 doi: 10.1038/s41467-017-01958-7. - DOI - PMC - PubMed
    1. Josephs KA, Hodges JR, Snowden JS, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol. 2011;122:137–153. doi: 10.1007/s00401-011-0839-6. - DOI - PMC - PubMed
    1. Hodges JR, Mitchell J, Dawson K, et al. Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain. 2010;133:300–306. doi: 10.1093/brain/awp248. - DOI - PubMed