Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct;24(10):1171-1181.
doi: 10.1007/s10147-019-01490-2. Epub 2019 Jul 18.

Immune checkpoint inhibitor-induced sarcoidosis-like granulomas

Pooja H Rambhia  1 , Barbara Reichert  1 , Jeffrey F Scott  1 , Ashley N Feneran  1 , Jordan A Kazakov  2 , Kord Honda  1   3 , Henry Koon  3   4 , Meg R Gerstenblith  5   6
Affiliations
Review

Immune checkpoint inhibitor-induced sarcoidosis-like granulomas

Pooja H Rambhia et al. Int J Clin Oncol. 2019 Oct.

Abstract

Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.

Keywords: CTLA-4; Drug reactions; Immune checkpoint inhibitor; Melanoma; PD-1; Sarcoidosis-like granuloma.

PubMed Disclaimer

References

    1. Dermatology. 2009;218(1):69-70 - PubMed
    1. Dermatology. 2009;219(1):25-31 - PubMed
    1. J Transl Med. 2009 May 20;7:35 - PubMed
    1. Nat Rev Rheumatol. 2011 Jul 12;7(8):457-67 - PubMed
    1. J Clin Oncol. 2012 Jan 10;30(2):e7-e10 - PubMed

MeSH terms

Substances

LinkOut - more resources