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. 2020 Mar;45(2):202-206.
doi: 10.1111/ced.14054. Epub 2019 Oct 20.

Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q Q Quartey  1 , R J Miller  2 , B L Pinsker  2 , U J Okoh  2 , W D Shipman  3 , B A George  4 , C C Nwizu  4 , L A Barnes  5 , M L Kerns  2 , J A Caffrey  6 , O Aliu  6 , I D Brown  2 , F Succaria  2 , J P Maynard  7 , A S Herbert  1 , S Kang  2 , L S Miller  2 , G A Okoye  2   8 , A S Byrd  2   8
Affiliations

Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q Q Quartey et al. Clin Exp Dermatol. 2020 Mar.

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

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