Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;28(10):1995-2001.
doi: 10.1002/pon.5179. Epub 2019 Aug 8.

Pediatric bone marrow transplantation: Psychopathologic features in recipients along with siblings

Semih Erden  1 , Bülent Barış Kuşkonmaz  2 , Duygu Uçkan Çetinkaya  2 , Fatih Ünal  3 , Berna Özsungur  3
Affiliations

Pediatric bone marrow transplantation: Psychopathologic features in recipients along with siblings

Semih Erden et al. Psychooncology. 2019 Oct.

Abstract

Objective: To analyze the development of psychopathology in recipients along with their donor and nondonor siblings and the relationship with the bone marrow transplantation (BMT) process.

Methods: All children were interviewed using the Kiddie Schedule for Affective Disorders and Schizophrenia to assess psychopathology. The depression and anxiety symptoms and self-esteem of children and adolescents were evaluated using the Children's Depression Inventory, State-Trait Anxiety Inventory for Children, State-Trait Anxiety Inventory, and Rosenberg Self-Esteem Scale.

Results: In this study, the depressive symptom level was found significantly higher in the donor group compared with the nondonor group. State anxiety symptoms were higher in the BMT group (P < .05). There were no significant differences in trait anxiety symptoms. Self-respect was higher in children in the donor group compared with those in the BMT group (P < .05). During the transplant process, children with bone marrow transplants had a higher prevalence of depression, anxiety disorder, and attention-deficit/hyperactivity disorder, and nondonor siblings had a higher prevalence of depressive disorder, anxiety disorder, and attention-deficit/hyperactivity disorder compared with society in general.

Conclusion: Physicians should deal with the family as a whole, not just their patient, and should be aware of the psychiatric risk of other siblings during the assessment.

Keywords: anxiety; bone marrow transplantation; cancer; child; depression; oncology; pediatric; psychopathology; self-esteem.

PubMed Disclaimer

References

REFERENCES

    1. Barrera M, Pringle LB, Sumbler K, Saunders F. Quality of life and behavioral adjustment after pediatric bone marrow transplantation. Bone Marrow Transplant. 2000;26(4):427-435.
    1. Meyers CA, Weitzner M, Byrne K, Valentine A, Champlin RE, Przepiorka D. Evaluation of the neurobehavioral functioning of patients before, during, and after bone marrow transplantation. J Clin Oncol. 1994;12(4):820-826.
    1. Pot-Mees CC. The psychosocial effects of bone marrow transplantation in children. Eburon Delft; 1989.
    1. Phipps S, Dunavant M, Lensing S, Rai SN. Acute health-related quality of life in children undergoing stem cell transplant: II. Medical and demographic determinants. Bone Marrow Transplant. 2002;29(5):435-442.
    1. Felder-Puig R, Peters C, Matthes-Martin S, et al. Psychosocial adjustment of pediatric patients after allogeneic stem cell transplantation. Bone Marrow Transplant. 1999;24(1):75-80.