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. 2019 Sep 4;14(17):1575-1579.
doi: 10.1002/cmdc.201900356. Epub 2019 Aug 7.

Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells

Syed Muhammad Usama  1 , Zhengyang Jiang  1 , Kathryn Pflug  2 , Raquel Sitcheran  2 , Kevin Burgess  1
Affiliations

Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells

Syed Muhammad Usama et al. ChemMedChem. .

Abstract

We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viability of a glioblastoma cell line with significantly greater potency than dasatinib alone, MHI-148 alone, or a mixture of dasatinib and MHI-148 at the same concentration. It was also used to successfully image a subcutaneous glioblastoma tumor in vivo.

Keywords: cancer; cyanine; glioblastoma; imaging agents; tumor targeting.

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