Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct;92(1102):20190107.
doi: 10.1259/bjr.20190107. Epub 2019 Jul 31.

Update in pediatric nasopharyngeal undifferentiated carcinoma

Line Claude  1 , Emmanuel Jouglar  2 , Loig Duverge  1   3 , Daniel Orbach  4
Affiliations
Review

Update in pediatric nasopharyngeal undifferentiated carcinoma

Line Claude et al. Br J Radiol. 2019 Oct.

Abstract

Many of the principles established in adults with undifferentiated nasopharyngeal carcinoma (NPC) apply to children, adolescents and young adults. However, NPC in young patients should be distinguished from the adult form by several points. This review focuses mainly on differences between adult and pediatric NPC. The role of biology and genetics in pediatric NPC is discussed. Systemic treatment modalities including type of chemotherapy induction, timing of treatment, role of immunotherapy as adjuvant treatment, or in relapsing/ metastatic diseases are reported. Radiation modalities (doses, techniques…) in children are also reviewed. Long-term effects including secondary cancers are finally be discussed in this young NPC population.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Representation of the RT doses levels according to the tumor and nodal involvements after induction chemotherapy. RT doses are adapted according to the risk of relapse, leading to several levels of doses (prophylactic = PTV0, standard risk = PTV1, high risk = PTV2). RT doses are also adapted to the chemotherapy response in several current guidelines. Chemo, chemotherapy; RT, radiotherapy; PTV, planning target volume
Figure 2.
Figure 2.
Principle of SIB as compared with sequential treatments (Gy: Grays). SIB, simultaneous integrated boost.
See this image and copyright information in PMC

References

    1. Qiu W-Z, Peng X-S, Xia H-Q, Huang P-Y, Guo X, Cao K-J. A retrospective study comparing the outcomes and toxicities of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy for the treatment of children and adolescent nasopharyngeal carcinoma. J Cancer Res Clin Oncol 2017; 143: 1563–72. doi: 10.1007/s00432-017-2401-y - DOI - PMC - PubMed
    1. Pastore G, De Salvo GL, Bisogno G, Dama E, Inserra A, Cecchetto G, et al. . Evaluating access to pediatric cancer care centers of children and adolescents with rare tumors in Italy: the TREP project. Pediatr Blood Cancer 2009; 53: 152–5. doi: 10.1002/pbc.22049 - DOI - PubMed
    1. Casanova M, Bisogno G, Gandola L, Cecchetto G, Di Cataldo A, Basso E, et al. . A prospective protocol for nasopharyngeal carcinoma in children and adolescents: the Italian rare tumors in pediatric age (TREP) project. Cancer 2012; 118: 2718–25. doi: 10.1002/cncr.26528 - DOI - PubMed
    1. Rodriguez-Galindo C, Wofford M, Castleberry RP, Swanson GP, London WB, Fontanesi J, et al. . Preradiation chemotherapy with methotrexate, cisplatin, 5-fluorouracil, and leucovorin for pediatric nasopharyngeal carcinoma. Cancer 2005; 103: 850–7. doi: 10.1002/cncr.20823 - DOI - PubMed
    1. Desandes E, Clavel J, Berger C, Bernard J-L, Blouin P, de Lumley L, et al. . Cancer incidence among children in France, 1990-1999. Pediatr Blood Cancer 2004; 43: 749–57. doi: 10.1002/pbc.20148 - DOI - PubMed

MeSH terms