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. 2019 Jul 19;34(3).
doi: 10.1515/dmpt-2018-0041.

Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations

Edward Valencia Ayala  1 , Pool Marcos Carbajal  2 , Eduardo Barbosa Coelho  3 , Jose Sandoval Sandoval  4 , Alberto Salazar Granara  5
Affiliations

Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations

Edward Valencia Ayala et al. Drug Metab Pers Ther. .

Abstract

Background The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions), even considering the altitude (lowland <2500 m and highland >2500 m). Methods The polymorphism was analyzed by TaqMan genotyping assays in a group of 181 healthy unrelated Peruvian individuals. The comparison of genotype and allele frequencies of 3435C>T polymorphism was made with the Pearson test (X2), and, to calculate the genotype distributions, the Hardy-Weinberg equilibrium (HWE) was used. Results In all populations evaluated in this study, the genotype frequency distributions met HWE assumptions. The comparison between genotype and allele frequencies showed significant differences (p < 0.05), when the Andean, Coastal and Amazonian populations were compared. Also, significant differences (p < 0.05) were obtained when these populations were compared considering their altitudes. Likewise, in comparison with countries like USA, Finland, Nigeria and Kenya, the results showed significant differences (p < 0.05). Conclusions This investigation allowed us to establish the genotype and allele frequencies of 3435C>T polymorphism in different Peruvian populations, considering the geographic localization and even the altitude.

Keywords: ethnic population; gene polymorphism; genotyping; pharmacokinetics.

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