Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jul 19;14(1):130.
doi: 10.1186/s13014-019-1336-7.

Radiotherapy for recurrent central Giant cell granuloma: a case report

Qi Zhang  1   2 , Zelai He  1   2 , Gengming Wang  1   2 , Hao Jiang  3   4
Affiliations
Case Reports

Radiotherapy for recurrent central Giant cell granuloma: a case report

Qi Zhang et al. Radiat Oncol. .

Abstract

Background: Central giant cell granuloma (CGCG) is a rare, non-neoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. CGCG treatment and management is challenging for clinicians.

Case presentation: This report presents the treatment and management of recurrent, aggressive CGCG after surgical resection. After informed consent was obtained, the patient underwent radiotherapy. The lesion size was reduced significantly, with no evidence of recurrence or malignant transformation.

Conclusions: This treatment experience indicates that radiotherapy can be used as a rescue treatment for complicated CGCG involving vital neurovascular structures of the cranial base.

Keywords: Central giant cell granuloma; Radiotherapy; Surgical resection.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Clinical features of the patient. a Pathological features: hypertrophic shuttle fibroblasts scattered in the distribution of multicore giant cells; cells of different sizes; cells with small nuclei; no overtly mitotic cells; visible interstitial bleeding. b Pretreatment computed tomography (CT): the lesion involved in the right nasal cavity, maxillary sinus, right frontal lobe, right eye, and skull base bone. c Pretreatment MRI: isointense signals on T1-weighted imaging and more heterogeneous signals on T2-weighted imaging. The lesion primarily involved the nasal cavity, nasopharynx, bilateral ethmoid sinus, extraocular muscles, and frontal lobe of the parenchyma. Additionally, the bilateral ventricle was compressed. d Posttreatment MRI scan: right nasal cavity, maxillary sinus, ethmoid sinus and right side of the skin showed mixed T1 and T2 signals, and the edge was unclear; uneven signals showed enhanced abnormalities of the signal and unevenness near the maxillofacial bone; right frontal sinus expansion was observed, and the sinus cavity showed irregular cystic short T1 and slight T2 signals. The right frontal sinus showed an abnormal signal, which was considered a “mucous cyst”. e Pretreatment appearance. f Posttreatment appearance
See this image and copyright information in PMC

References

    1. Reddy V, Saxena S, Aggarwal P, Sharma P, Reddy M. Incidence of central giant cell granuloma of the jaws with clinical and histological confirmation: an archival study in northern India. Br J Oral Maxillofac Surg. 2012;50(7):668–672. doi: 10.1016/j.bjoms.2011.10.015. - DOI - PubMed
    1. Rihani J, Kutz JW, Isaacson B. Hearing outcomes after surgical drainage of petrous apex cholesterol granuloma. J Neurol Surg B. 2015;76(03):171–175. doi: 10.1055/s-0034-1395489. - DOI - PMC - PubMed
    1. Katherine T, Grigoris V, George K, Fotis I. Central Giant cell granuloma of the jaws: a clinical study of 17 cases and a review of the literature. Ann Otol Rhinol Laryngol. 2011;120(3):167–174. doi: 10.1177/000348941112000305. - DOI - PubMed
    1. Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6(1):159–175. doi: 10.1016/0030-4220(53)90151-0. - DOI - PubMed
    1. Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283–1309. doi: 10.1148/radiographics.21.5.g01se251283. - DOI - PubMed

Publication types

LinkOut - more resources