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Comment
. 2019 Aug 5;151(8):970.
doi: 10.1085/jgp.201912432. Epub 2019 Jul 19.

How dendritic spines shape calcium dynamics

Ben Short
Comment

How dendritic spines shape calcium dynamics

Ben Short. J Gen Physiol. .

Abstract

JGP study develops mathematical model that describes how calcium signaling could be influenced by spine geometry and ultrastructure.

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Figures

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Miriam Bell (left), Padmini Rangamani (right), and colleagues develop a 3-D multicompartment reaction–diffusion model of calcium dynamics in dendritic spines. The model shows that altering the shape of the spine head or the specialized ER known as the spine apparatus has complex, nonlinear effects on calcium’s spatial distribution 5 ms after stimulation.
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References

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