Amino acids in post-stroke rehabilitation

Abstract

Objectives: Patients with stroke are prone to disability due to muscle hypercatabolism. We aim to review this concept based on available data on benefits of amino acid supplementation in post-stroke rehabilitation.Method: The search was performed on Medline and Embase in January 2019. Randomized controlled studies, observational studies and case reports conducted in the last 15 years on the supplementation of amino acids in post-stroke rehabilitation patients were included.Result: Amino acids prevent muscle hypercatabolism in post stroke patients by suppressing myofibrillar protein and skeletal muscle degradation. Stroke patients supplemented with amino acids led to an improvement of functional and physical performance.Discussion: Muscle protein hypercatabolism and sequestration of amino acids from skeletal muscles occur cyclically in post-stroke patients to counter each other. There is a resultant deficit of amino acids which is unmet. Amino acids have antiproteolytic effect. Its supplementation prevents muscle wasting and improves rehabilitation by promoting physical performance, muscle strength, mass, and function.

Keywords: Amino acids; disability; muscle hypercatabolism; paresis; proteolysis; rehabilitation; sarcopenia; stroke.