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. 2019 Jul 21;8(7):1069.
doi: 10.3390/jcm8071069.

Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus

Iginio Colaiori  1 , Raffaele Izzo  2 , Emanuele Barbato  3 , Danilo Franco  2 , Giuseppe Di Gioia  1   2 , Antonio Rapacciuolo  2 , Jozef Bartunek  1 , Costantino Mancusi  2 , Maria Angela Losi  2 , Teresa Strisciuglio  2 , Maria Virginia Manzi  2 , Giovanni de Simone  2 , Bruno Trimarco  2 , Carmine Morisco  2
Affiliations

Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus

Iginio Colaiori et al. J Clin Med. .

Abstract

Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown.

Objective: We evaluated the onset of DM in relation to the extent and severity of coronary atherosclerosis, using the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS), in patients with stable angina or acute coronary syndromes, referred for coronary angiography (CA).

Methods: Non-diabetic patients that underwent CA for the first time were included, and the SS was computed. Predictors of DM onset in low, medium, and high SSs were investigated.

Results: Five hundred and seventy patients were included, and the mean SS was 6.3 ± 7.6. During a median follow-up of 79 months (interquartile range (IQR): 67-94), 74 patients (13%) developed DM. The risk of DM onset was significantly higher in the patients with a medium or high SS (hazard ratio (HR)-95% confidence interval (CI): 16 (4-61), p < 0.0001; and 30 (9-105), p < 0.0001, vs low SS, respectively), even after adjustment for obesity, history of hypertension, impaired fasting glucose, and cardiovascular therapy.

Conclusions: The severity and extent of the coronary atherosclerosis, evaluated by the SS, is a strong and independent predictor of the development of DM in patients, referred to CA.

Keywords: atherosclerosis; coronary angiography; coronary artery disease; diabetes mellitus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Rate of type 2 diabetes mellitus (DM) in the three SYNTAX score (SS) levels.
Figure 2
Figure 2
Cox regression time to event analysis for type 2 diabetes mellitus onset, in the function of the three SS levels.
See this image and copyright information in PMC

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