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doi: 10.1016/j.jid.2019.04.001.
Gene Therapy for Skin Fragility Diseases: The New Generation
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- PMID: 31331444
- DOI: 10.1016/j.jid.2019.04.001
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Gene Therapy for Skin Fragility Diseases: The New Generation
J Invest Dermatol.
2019 Aug.
Free article
Abstract
Ex vivo gene therapy is a promising approach to treat devastating skin fragility diseases. March et al. and Takashima et al. report that programmable nucleases-TALENs and CRISPR/Cas9-can safely and efficiently correct genetic defects in cultured adult skin cells, paving the way for broader clinical applications of gene therapies in dermatology.
Copyright © 2019 The Author. Published by Elsevier Inc. All rights reserved.
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