Variable expression of Lactobacillus casei cell wall-induced coronary arteritis: an animal model of Kawasaki's disease in selected inbred mouse strains

Abstract

Mice receiving a single intraperitoneal injection of Lactobacillus casei cell wall fragments in aqueous suspension develop an asymmetric inflammatory coronary arteritis which histologically mimics the lesions seen in the coronary arteritis of children with Kawasaki's disease. A large variety of mice with genetically determined defects of the immune system were evaluated in this study to determine the influence of these defects on disease expression. Only the C3H/Hej mouse with defective macrophage function and poor production of IL-1 and TNF following stimulation with LPS failed to develop disease. This study suggests that further evaluation of macrophage function in children with Kawasaki's disease may provide important clues to its pathogenesis and treatment.