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Review
. 2019:91:123-162.
doi: 10.1016/bs.acc.2019.03.004. Epub 2019 May 10.

Advances in HER2 testing

Yun Chen  1 , Liang Liu  2 , Ronghua Ni  2 , Weixian Zhou  2
Affiliations
Review

Advances in HER2 testing

Yun Chen et al. Adv Clin Chem. 2019.

Abstract

HER2-positive breast cancer is a particularly aggressive type of breast cancer. Indication of HER2 positivity is essential for its treatment. In addition to a few FDA-approved methods such as immunohistochemical (IHC) detection of HER2 protein expression and in situ hybridization (ISH) assessment of HER2 gene amplification, several novel methods have been developed for HER2 testing in recent years. This chapter provides an overview of HER2 testing with emphasis on those new methods.

Keywords: Breast cancer; FISH; Gene; HER2 testing; IHC; Methods in development; Protein.

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