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Review
. 2019 Sep;26(6):358-360.
doi: 10.1016/j.arcped.2019.06.005. Epub 2019 Jul 19.

Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review

M-S Agier  1 , N Chollet  2 , E Bediou  3 , M Boyer Gervoise  4 , A-P Jonville-Bera  5
Affiliations
Review

Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review

M-S Agier et al. Arch Pediatr. 2019 Sep.

Abstract

We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondary to therapeutic doses of acetaminophen. Hypothermia after a therapeutic dose is a very rare side effect of acetaminophen. Several hypotheses have been made but the exact mechanism remains unknown.

Keywords: Acetaminophen; Hypothermia; Pediatrics.

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