LOX-1: Its cytotopographical variance and disease stress

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a canonical receptor for oxidized LDL (oxLDL) among the known modified LDL particles. Topographical variance on LOX-1 expression in different cell types and its influence on the atherogenic potential of the particular cell type is the main focus of this review. Characteristic features of LOX-1 on the atherogenic potential of aortic endothelial cells, macrophages, platelets, and vascular smooth muscle cells have been discussed. Nonspecificity of ligands, besides oxLDL, is also the highlight of this review to show the chameleon characteristics in the functional activity of the receptor protein. Induction of LOX-1 has been reported in diseases like atherosclerosis, diabetes, and hypertension, as well as in the inflammatory response of immune reactions. The expression of LOX-1 is upregulated by the vicious cycle of stimulatory response from proatherogenic molecules.

Keywords: atherosclerosis; diabetes; hypertension; inflammation; oxLDL receptor; oxidized LDL.