doi: 10.1111/j.1349-7006.1988.tb01614.x.
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine
Affiliations
- PMID: 3133336
- PMCID: PMC5917507
- DOI: 10.1111/j.1349-7006.1988.tb01614.x
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Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine
Jpn J Cancer Res.
1988 Apr.
Abstract
Studies were made on potential modifying effects of phenobarbital (PB) and carbazole on tumor development induced by N-bis(2-hydroxypropyl)nitrosamine (DHPN), a wide-spectrum carcinogen in rats. Effects on the lung, thyroid, kidney, bladder and liver were investigated. Male F344 rats were given 0.2% DHPN in their drinking water for 1 week and then 0.05% PB or 0.6% carbazole in their diet for 50 weeks. Control animals were treated with either DHPN or PB or carbazole only. Neither PB nor carbazole affected the incidence or histology of lung tumors. However, PB promoted the development of thyroid tumors and preneoplastic lesions of the liver, while carbazole promoted the induction of renal pelvic tumors.
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References
-
- ) Peraino , C. , Fry , R. J. M. and Staffeldt , E.Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2‐acetylaminofluorene . Cancer Res. , 31 , 1506 – 1512 ( 1971. ). - PubMed
-
- ) Hirose , M. , Shirai , T. , Tsuda , H. , Fukushima , S. , Ogiso , T. and Ito , N.Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N‐ethyl‐N‐hydroxyethyl‐nitrosamine orally . Carcinogenesis , 2 , 1299 – 1302 ( 1981. ). - PubMed
-
- ) Kitagawa , T. and Sugano , H.Enhancing effect of phenobarbital on the development of enzyme‐altered islands and hepatocellular carcinomas initiated by 3′‐methyl‐4‐(dimethylamino)azobenzene or diethylnitrosamine . Gann , 69 , 679 – 687 ( 1978. ). - PubMed
-
- ) Ward , J. M.Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms . J. Natl. Cancer Inst. , 71 , 815 – 823 ( 1983. ). - PubMed
-
- ) International Agency for Research on Cancer Phenobarbital and phenobarbital sodium . In“Some Miscellaneous Pharmaceutical Substances,” IARC Monograph on Evaluation of the Carcinogenic Risk of Chemicals in Man , Vol. 13 , pp. 157 – 181 ( 1977. ). IARC; , Lyon .
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