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Review
. 2019 Jul-Sep;13(3):231-236.
doi: 10.4103/sja.SJA_817_18.

Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting

Anh L Ngo  1 , Vwaire Orhurhu  1 , Ivan Urits  1 , Edwin O Delfin  1 , Medha Sharma  2 , Mark R Jones  1 , Omar Viswanath  3   4   5 , Richard D Urman  6
Affiliations
Review

Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting

Anh L Ngo et al. Saudi J Anaesth. 2019 Jul-Sep.

Abstract

In this review, we evaluate recent literature on use of ER granisetron in clinical practice as compared with current antiemetics and describe its potential uses for perioperative PONV prophylaxis and treatment. Recent literature was evaluated on ER granisetron use compared with currently used antiemetic agents ondansetron, droperidol, metoclopramide, promethazine, and dexamethasone with a focus on procedural anti-emesis. Though promising great effect, application of extended release granisetron to clinical use may be limited by it's increased relative cost.

Keywords: 5-HT3 antagonists; anti-emetics; pharmacotherapy; post-operative nausea and vomiting.

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Conflict of interest statement

There are no conflicts of interest.

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