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. 2019 Jul 3:10:843.
doi: 10.3389/fphys.2019.00843. eCollection 2019.

Supervised Physical Training Enhances Muscle Strength but Not Muscle Mass in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Systematic Review and Meta-Analysis

Ziyuan Chen  1 , Yuan Zhang  2 , Chunyan Lu  3 , Hao Zeng  4 , Moritz Schumann  1   2   5 , Sulin Cheng  1   2   6
Affiliations

Supervised Physical Training Enhances Muscle Strength but Not Muscle Mass in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Systematic Review and Meta-Analysis

Ziyuan Chen et al. Front Physiol. .

Erratum in

Abstract

Introduction: Androgen deprivation therapy (ADT) is considered the basic treatment for advanced prostate cancer, but it is highly associated with detrimental changes in muscle mass and muscle strength. The aim of this meta-analysis was to investigate the effects of supervised physical training on lean mass and muscle strength in prostate cancer patients undergoing ADT. Methods: A systematic literature search was performed using MEDLINE, Embase, and ScienceDirect until October 2018. Only studies that examined both muscle mass and strength in prostate cancer patients undergoing ADT were included. Outcomes of interest were changes in lean body mass (surrogate for muscle mass) as well as upper and lower body muscle strength. The meta-analysis was performed with fixed-effects models to calculate mean differences between intervention and no-training control groups. Results: We identified 8,521 publications through the search of the following key words: prostate cancer, prostate tumor, prostate carcinoma, prostate neoplasm, exercise, and training. Out of these studies, seven randomized controlled trials met the inclusion criteria and where included in the analysis. No significant mean differences for changes in lean mass were observed between the intervention and control groups (0.49 kg, 95% CI: -0.76, 1.74; P = 0.44). In contrast, the mean difference for muscle strength was significant both in chest (3.15 kg, 95% CI: 2.46, 3.83; P < 0.001) and in leg press (27.46 kg, 95% CI: 15.05, 39.87; p < 0.001). Conclusion: This meta-analysis provides evidence that low- to moderate-intensity resistance and aerobic training is effective for increasing muscle strength but may not be sufficient to affect muscle mass in prostate cancer patients undergoing ADT. The underlying mechanisms for this maladaptation may in part be explained by an insufficient stimulus induced by the training regimens as well as a delayed initiation of training in relation to the start of ADT. When interpreting the present findings, one should bear in mind that the overall number of studies included in this review was rather low, emphasizing the need for further studies in this field.

Keywords: ADT; androgen suppression; exercise medicine; exercise oncology; lean mass; strength training.

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Figures

Figure 1
Figure 1
Screening chart.
Figure 2
Figure 2
Summary of risk of bias assessment.
Figure 3
Figure 3
Forest plots for pooled mean differences in lean mass with corresponding 95% CI.
Figure 4
Figure 4
Forest plots for pooled mean differences in chest press strength with corresponding 95% CI.
Figure 5
Figure 5
Forest plots for pooled mean differences in leg press strength with corresponding 95% CI.
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References

    1. Ahmadi H., Daneshmand S. (2014). Androgen deprivation therapy for prostate cancer: long-term safety and patient outcomes. Patient Relat. Outcome Meas. 5, 63–70. 10.2147/PROM.S52788 - DOI - PMC - PubMed
    1. Ahtiainen J. P., Pakarinen A., Alen M., Kraemer W. J., Häkkinen K. (2003). Muscle hypertrophy, hormonal adaptations and strength development during strength training in strength-trained and untrained men. Eur. J. Appl. Physiol. 89, 555–563. 10.1007/s00421-003-0833-3 - DOI - PubMed
    1. American Cancer Society (2013). Cancer Facts and Figures 2013. Atlanta, GA: American Cancer Society.
    1. American College of Sports Medicine (2009). American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med. Sci. Sports Exerc. 41, 687–708. 10.1249/MSS.0b013e3181915670 - DOI - PubMed
    1. Araujo A. B., Esche G. R., Kupelian V., O'Donnell A. B., Travison T. G., Williams R. E., et al. . (2007). Prevalence of symptomatic androgen deficiency in men. J. Clin. Endocrinol. Metab. 92, 4241–4247. 10.1210/jc.2007-1245 - DOI - PubMed

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