Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul 5:10:874.
doi: 10.3389/fphys.2019.00874. eCollection 2019.

Novel Mechanisms in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

Ishan Lakhani  1   2 , Keith Sai Kit Leung  1   2   3 , Gary Tse  1   2 , Alex Pui Wai Lee  1
Affiliations

Novel Mechanisms in Heart Failure With Preserved, Midrange, and Reduced Ejection Fraction

Ishan Lakhani et al. Front Physiol. .
No abstract available

Keywords: LV dyssynchrony; inflammation; mortality; network analysis; phenomapping.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A schematic diagram demonstrating the current theories of underlying pathophysiology in different classes of heart failure. (A) Pathophysiology of HFrEF. (B) Pathophysiology of HFpEF. (C) Role of Frailty in HFpEF. (D) Role of LV Dyssynchrony in HF.
See this image and copyright information in PMC

References

    1. Ahmad T., Fiuzat M., Neely B., Neely M. L., Pencina M. J., Kraus W. E., et al. . (2014). Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure. JACC Heart Fail. 2, 260–268. 10.1016/j.jchf.2013.12.004 - DOI - PMC - PubMed
    1. Alehagen U., Benson L., Edner M., Dahlström U., Lund L. H. (2015). Association between use of statins and mortality in patients with heart failure and ejection fraction of ≥50. Circ. Heart Fail. 8, 862–870. 10.1161/CIRCHEARTFAILURE.115.002143 - DOI - PubMed
    1. Bloom M. W., Greenberg B., Jaarsma T., Januzzi J. L., Lam C. S. P., Maggioni A. P., et al. . (2017). Heart failure with reduced ejection fraction. Nat. Rev. Dis. Prim. 3:17058. 10.1038/nrdp.2017.58 - DOI - PubMed
    1. Bonow R. O., Vitale D. F., Bacharach S. L., Maron B. J., Green M. V. (1988). Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects. J. Am. Coll. Cardiol. 11, 50–58. 10.1016/0735-1097(88)90166-0 - DOI - PubMed
    1. Borlaug B. A. (2014). The pathophysiology of heart failure with preserved ejection fraction. Nat. Rev. Cardiol. 11, 507–515. 10.1038/nrcardio.2014.83 - DOI - PubMed

LinkOut - more resources