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Review
. 2019 Jul-Sep;10(3):100-106.
doi: 10.4103/japtr.JAPTR_26_19.

Advances in orally targeted drug delivery to colon

Nagina Belali  1   2 , Nasrul Wathoni  1 , Muchtaridi Muchtaridi  3
Affiliations
Review

Advances in orally targeted drug delivery to colon

Nagina Belali et al. J Adv Pharm Technol Res. 2019 Jul-Sep.

Abstract

Colon-specific drug delivery is critical for treating diseases of colon, such as colon cancer, amoebiasis, irritable bowel syndrome, and inflammatory bowel disease. This study reviews the effects of targeted oral drug delivery on patient by measuring the accurate administration of the drug to specific disease spot, thus enhancing the therapeutic efficacy and provides better therapeutic outcomes. Medically targeted delivery to colon produces local effect on the diseases and hinders the systemic toxic effects of drugs. The delivery of therapeutics to the specific diseased part of colon has its merits over systemic drug delivery, albeit has some obstacles and problems. Colon drug delivery can be used to create both systemic and local effects. Many advanced approaches are used, such as conventional methods for drug release to colon, delayed release dosage forms, nanoparticles, carbon nanotubes, dendrimers, and alginate coated microparticles. This concise review summarizes and elaborates the details of different techniques and strategies on targeted oral drug delivery to colon as well as studies the advantages, disadvantages, and limitations to improve the application of drug in the part of the affected colon.

Keywords: Alginate; carbon nanotubes; dendrimers; drug delivery; microparticles; nanoparticles.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Changes in microbial and physiological pH of gastrointestinal tract in inflammatory bowel disease patient
Figure 2
Figure 2
Conventional systems for colonic drug delivery
Figure 3
Figure 3
Bacterial transformation of sulfasalazine
See this image and copyright information in PMC

References

    1. Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, et al. Nanoparticle-based oral delivery systems for colon targeting: Principles and design strategies. Sci Bull. 2016;61:670–81.
    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86. - PubMed
    1. Jaferian S, Negahdari B, Eatemadi A. Colon cancer targeting using conjugates biomaterial 5-flurouracil. Biomed Pharmacother. 2016;84:780–8. - PubMed
    1. Agüero L, Zaldivar-Silva D, Peña L, Dias ML. Alginate microparticles as oral colon drug delivery device: A review. Carbohydr Polym. 2017;168:32–43. - PubMed
    1. Vaidya A, Jain S, Agrawal RK, Jain SK. Pectin-metronidazole prodrug bearing microspheres for colon targeting. J Saudi Chem Soc. 2015;19:257–64.