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Review
. 2019 Jun;8(6):1850-1854.
doi: 10.4103/jfmpc.jfmpc_296_19.

Role of microRNAs in stroke recovery

Agam Bansal  1 , Rana Prathap  1 , Samiksha Gupta  1 , Aditi Chaurasia  1 , Pooja Chaudhary  1
Affiliations
Review

Role of microRNAs in stroke recovery

Agam Bansal et al. J Family Med Prim Care. 2019 Jun.

Abstract

Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery.

Keywords: Angiogenesis; axonal growth; microRNAs; neurogenesis; stroke; synaptic plasticity.

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Conflict of interest statement

There are no conflicts of interest.

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