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. 1988 Jun 1;167(6):1781-90.
doi: 10.1084/jem.167.6.1781.

An enhancer factor defect in a mutant Burkitt lymphoma cell line

W Koch  1 , S Candeias, J Guardiola, R Accolla, C Benoist, D Mathis
Affiliations

An enhancer factor defect in a mutant Burkitt lymphoma cell line

W Koch et al. J Exp Med. .

Abstract

RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.

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