West Nile Virus
- PMID: 31334966
- Bookshelf ID: NBK544246
West Nile Virus
Excerpt
West Nile virus is an enveloped, single-stranded RNA virus and member of the Flaviviridae family. It is an arbovirus transmitted to humans by the bite of a mosquito.
It is known to cause disease in humans with a wide array of presentations. These range from the asymptomatic infected patient to fever and malaise to florid neurological deficits secondary to encephalitis. However, most people infected with West Nile virus are asymptomatic. Approximately 1 in 4 patients experience fever with symptoms of a viral syndrome, while around 1 in 200 develops neuroinvasive disease.
Originally seen in Africa, West Nile virus began showing up throughout Europe, Asia, and North America in the 1990s. It is now present throughout much of the world.
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Sections
- Continuing Education Activity
- Introduction
- Etiology
- Epidemiology
- Pathophysiology
- History and Physical
- Evaluation
- Treatment / Management
- Differential Diagnosis
- Prognosis
- Complications
- Deterrence and Patient Education
- Pearls and Other Issues
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Zou S, Foster GA, Dodd RY, Petersen LR, Stramer SL. West Nile fever characteristics among viremic persons identified through blood donor screening. J Infect Dis. 2010 Nov 01;202(9):1354-61. - PubMed
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- O'Leary DR, Kuhn S, Kniss KL, Hinckley AF, Rasmussen SA, Pape WJ, Kightlinger LK, Beecham BD, Miller TK, Neitzel DF, Michaels SR, Campbell GL, Lanciotti RS, Hayes EB. Birth outcomes following West Nile Virus infection of pregnant women in the United States: 2003-2004. Pediatrics. 2006 Mar;117(3):e537-45. - PubMed
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- Nash D, Mostashari F, Fine A, Miller J, O'Leary D, Murray K, Huang A, Rosenberg A, Greenberg A, Sherman M, Wong S, Layton M, 1999 West Nile Outbreak Response Working Group The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med. 2001 Jun 14;344(24):1807-14. - PubMed
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- Williamson PC, Custer B, Biggerstaff BJ, Lanciotti RS, Sayers MH, Eason SJ, Dixon MR, Winkelman V, Lanteri MC, Petersen LR, Busch MP. Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic. Epidemiol Infect. 2017 Sep;145(12):2536-2544. - PMC - PubMed
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