Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Craniosynostosis

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Craniosynostosis

Elodie M. Betances et al.
Free Books & Documents

Excerpt

Craniosynostosis occurs due to the premature in-utero fusion of one or more cranial sutures. These sutures allow for passage through the birth canal and, later in development, allow the expansion and growth of the underlying brain. When these sutures close prematurely, the head shape becomes altered depending on the sutures involved. Most cases involve a single suture and are classified as non-syndromic. However, Crouzon, Pfeiffer, and Apert syndromes have been associated with multi-sutural craniosynostosis. The treatment of craniosynostosis involves surgical intervention to unlock the fused sutures, ensuring unrestricted brain development and correcting cosmetic deformities.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Elodie Betances declares no relevant financial relationships with ineligible companies.

Disclosure: Magda Mendez declares no relevant financial relationships with ineligible companies.

Disclosure: Torin Karsonovich declares no relevant financial relationships with ineligible companies.

Disclosure: Joe Das declares no relevant financial relationships with ineligible companies.

References

    1. Hersh DS, Hughes CD. Syndromic Craniosynostosis: Unique Management Considerations. Neurosurg Clin N Am. 2022 Jan;33(1):105-112. - PubMed
    1. Lajeunie E, Crimmins DW, Arnaud E, Renier D. Genetic considerations in nonsyndromic midline craniosynostoses: a study of twins and their families. J Neurosurg. 2005 Oct;103(4 Suppl):353-6. - PubMed
    1. Johnson D, Wilkie AO. Craniosynostosis. Eur J Hum Genet. 2011 Apr;19(4):369-76. - PMC - PubMed
    1. Wilkie AO, Byren JC, Hurst JA, Jayamohan J, Johnson D, Knight SJ, Lester T, Richards PG, Twigg SR, Wall SA. Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis. Pediatrics. 2010 Aug;126(2):e391-400. - PMC - PubMed
    1. Azoury SC, Reddy S, Shukla V, Deng CX. Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis. Int J Biol Sci. 2017;13(12):1479-1488. - PMC - PubMed

Publication types

LinkOut - more resources