Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Sep;39(5):452-455.
doi: 10.1097/PGP.0000000000000627.

Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation

Stephanie L Skala, Patricia A Gregg, James W Orr Jr, Aaron M Udager, Noah A Brown, Kathleen R Cho
Case Reports

Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation

Stephanie L Skala et al. Int J Gynecol Pathol. 2020 Sep.

Abstract

Mesonephric adenocarcinoma is a rare tumor, accounting for <1% of cervical cancers. Well-differentiated mesonephric adenocarcinoma can be difficult to distinguish from diffuse mesonephric hyperplasia. Herein, we report a case of well-differentiated mesonephric adenocarcinoma with an FGFR2 mutation not previously reported in the literature. Nonselective tyrosine kinase inhibitors or FGFR2 inhibitors may represent options for targeted therapy.

PubMed Disclaimer

References

    1. Takenaka M, Saito M, Iwakawa R, et al. Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing. Int J Oncol 2015;46:2389–98.
    1. Sneeden VD. Mesonephric lesions of the cervix; a practical means of demonstration and a suggestion of incidence. Cancer 1958;11:334–6.
    1. Moritani S, Ioffe OB, Sagae S, et al. Mitotic activity and apoptosis in endocervical glandular lesions. Int J Gynecol Pathol 2002;21:125–33.
    1. McCluggage WG, Oliva E, Herrington CS, et al. CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma. Histopathol 2003;43:144–50.
    1. Ordi J, Romagosa C, Tavassoli FA, et al. CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol 2003;27:178–86.

Publication types

Substances