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Comment
. 2019 Jul 22;50(2):130-131.
doi: 10.1016/j.devcel.2019.07.003.

Pulling the Roof Down on Anchored Nuclei

Charlotte R Pfeifer  1 , Dennis E Discher  2
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Pulling the Roof Down on Anchored Nuclei

Charlotte R Pfeifer et al. Dev Cell. .
Free article

Abstract

How a smooth epithelium becomes topographically patterned in development remains incompletely understood. In this issue of Developmental Cell,Ambrosini et al. (2019) investigate how dying cells specifically indent the apical surface, finding that apical actomyosin cables contract against the apoptotic nucleus, which itself is anchored basally to the extracellular matrix.

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