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Comparative Study
. 1988 Jun 10;16(11):5107-13.
doi: 10.1093/nar/16.11.5107.

Inhibition of DNA polymerase alpha by aphidicolin derivatives

L Arabshahi  1 , N Brown, N Khan, G Wright
Affiliations
Free PMC article
Comparative Study

Inhibition of DNA polymerase alpha by aphidicolin derivatives

L Arabshahi et al. Nucleic Acids Res. .
Free PMC article

Abstract

17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase alpha from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.

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References

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