doi: 10.1128/iai.23.3.706-710.1979.
Mitogenic activity of staphylococcal peptidoglycan
- PMID: 313370
- PMCID: PMC414223
- DOI: 10.1128/iai.23.3.706-710.1979
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Mitogenic activity of staphylococcal peptidoglycan
Infect Immun.
1979 Mar.
Abstract
Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.
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