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. 1979 Mar;23(3):706-10.
doi: 10.1128/iai.23.3.706-710.1979.

Mitogenic activity of staphylococcal peptidoglycan

R Dziarski, A Dziarski

Mitogenic activity of staphylococcal peptidoglycan

R Dziarski et al. Infect Immun. 1979 Mar.

Abstract

Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.

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