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Clinical Trial
. 1988:95 Suppl:S44-9.
doi: 10.1007/BF00172630.

Trazodone for deafferentation pain. Comparison with amitriptyline

V Ventafridda  1 , A Caraceni, L Saita, C Bonezzi, F De Conno, G Guarise, G Ramella, V Silvani, M Tamburini, F Toscani
Affiliations
Clinical Trial

Trazodone for deafferentation pain. Comparison with amitriptyline

V Ventafridda et al. Psychopharmacology (Berl). 1988.

Abstract

We report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic pain due to deafferentation. Forty five patients were admitted to the study; most of them with oncological peripheral nerve lesions. Almost all of them were already being treated with NSAID in association with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitriptyline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety and weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.

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References

    1. Pain. 1985 Sep;23(1):1-8 - PubMed
    1. Nouv Presse Med. 1979 Mar 10;8(11):843-5 - PubMed
    1. Ann Neurol. 1983 Feb;13(2):160-4 - PubMed
    1. Ann Neurol. 1983 Apr;13(4):462-5 - PubMed
    1. Neuropharmacology. 1980 Dec;19(12):1165-73 - PubMed

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