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Review
. 1988;12(2-3):165-72.
doi: 10.1016/0278-5846(88)90034-6.

Prevention of progression of Parkinson's disease with antioxidative therapy

J D Grimes  1 , M N Hassan, J H Thakar
Affiliations
Review

Prevention of progression of Parkinson's disease with antioxidative therapy

J D Grimes et al. Prog Neuropsychopharmacol Biol Psychiatry. 1988.

Abstract

1. Oxidative mechanisms in dopaminergic neurons may contribute to cell death and the progression of Parkinson's Disease. 2. The free radical auto-toxicity concept has scientific evidence to support it. 3. Clinical trials are underway to assess the protective effect of augmenting the free radical scavenging system with vitamin E and inhibiting catecholamine oxidation with deprenyl.

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