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. 2019 Jul 23;19(1):727.
doi: 10.1186/s12885-019-5952-2.

L1TD1 - a prognostic marker for colon cancer

Affiliations

L1TD1 - a prognostic marker for colon cancer

Deepankar Chakroborty et al. BMC Cancer. .

Abstract

Background: Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.

Methods: Gene expression data was analyzed from three independent colon cancer microarray gene expression data sets (N = 1052). Survival analysis was performed for the three data sets, stratified by the expression level of the LINE-1 type transposase domain containing 1 (L1TD1). Correlation analysis was performed to investigate the role of the interactome of L1TD1 in colon cancer patients.

Results: We found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our results were in contrast to a previous study on medulloblastoma, where high expression of L1TD1 was linked with poor prognosis. Notably, in medulloblastoma L1TD1 was co-expressed with its interaction partners, whereas our analysis revealed lack of co-expression of L1TD1 with its interaction partners in colon cancer.

Conclusions: Our results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients.

Keywords: Biomarkers; Colon cancer; Human L1TD1 gene; Prognostic factors; Survival analysis.

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Conflict of interest statement

There are no financial or non-financial competing interests.

Figures

Fig. 1
Fig. 1
Survival curves for colon cancer. Kaplan-Meier curves showing disease-free survival for the three colon cancer data sets (a-c). The curves present survival data for the two groups of colon cancer patients based on L1TD1 expression level (high or low). The red curve corresponds to the patients with high L1TD1 expression and the black curve corresponds to the patients with low L1TD1 expression. The x-axis shows disease-free survival time in years and the y-axis shows the probability of disease-free survival. The risk table shows the number of patients at risk at the given time point
Fig. 2
Fig. 2
Co-expression of interaction partners of L1TD1. Heatmaps showing signed P-value of Spearman rank correlation for the 20 most significantly co-expressed interaction partners of L1TD1 determined on the basis of the seminoma and stem cell data sets. Co-expression in (a) seminoma and stem cell data sets, and (b) colon cancer data sets. The signed P-value of Spearman rank correlation was defined as 1 - P-value of Spearman rank correlation multiplied by the sign of the correlation

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