DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer

Charles A Ishak¹, Stephanie Lheureux^{1

2}, Daniel D De Carvalho^{3

4}

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada.
² Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.
³ Princess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada. Daniel.DeCarvalho@uhnresearch.ca.
⁴ Department of Medical Biophysics, University of Toronto. Toronto, Ontario, Canada.

PMID: 31337645
DOI: 10.1158/1078-0432.CCR-19-1797

Comment

DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer

Charles A Ishak et al. Clin Cancer Res. 2019.

. 2019 Oct 1;25(19):5729-5731.

doi: 10.1158/1078-0432.CCR-19-1797. Epub 2019 Jul 23.

Authors

Charles A Ishak¹, Stephanie Lheureux^{1

2}, Daniel D De Carvalho^{3

4}

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada.
² Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.
³ Princess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada. Daniel.DeCarvalho@uhnresearch.ca.
⁴ Department of Medical Biophysics, University of Toronto. Toronto, Ontario, Canada.

PMID: 31337645
DOI: 10.1158/1078-0432.CCR-19-1797

Abstract

Epithelial ovarian cancers (EOC) can be defined across different histologic subtypes by specific DNA methylation profiles which correlate with outcome. Identification of distinct EOC methylation subgroups emphasizes the role of epigenetic remodeling to establish unique EOC etiology during transformation, and harbors the potential to direct personalized medicine and patient care.See related article by Bodelon et al., p. 5937.

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Comment in

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity.
Bodelon C, Killian JK, Sampson JN, Anderson WF, Matsuno R, Brinton LA, Lissowska J, Anglesio MS, Bowtell DDL, Doherty JA, Ramus SJ, Talhouk A, Sherman ME, Wentzensen N. Bodelon C, et al. Clin Cancer Res. 2019 Oct 1;25(19):5937-5946. doi: 10.1158/1078-0432.CCR-18-3720. Epub 2019 May 29. Clin Cancer Res. 2019. PMID: 31142506 Free PMC article.

Comment on

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity.
Bodelon C, Killian JK, Sampson JN, Anderson WF, Matsuno R, Brinton LA, Lissowska J, Anglesio MS, Bowtell DDL, Doherty JA, Ramus SJ, Talhouk A, Sherman ME, Wentzensen N. Bodelon C, et al. Clin Cancer Res. 2019 Oct 1;25(19):5937-5946. doi: 10.1158/1078-0432.CCR-18-3720. Epub 2019 May 29. Clin Cancer Res. 2019. PMID: 31142506 Free PMC article.

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DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer

Affiliations

DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer

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