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Comment
. 2019 Aug 5;216(8):1726-1727.
doi: 10.1084/jem.20191183. Epub 2019 Jul 23.

Plastic fantastic innate lymphoid cells

Lewis L Lanier  1
Affiliations
Comment

Plastic fantastic innate lymphoid cells

Lewis L Lanier. J Exp Med. .

Abstract

In this issue of JEM, Nagasawa et al. (https://doi.org/10.1084/jem.20190490) have undertaken a detailed study of the cell surface phenotype, transcriptional profile, and cytokine secretion of ILC progenitor populations in human peripheral blood and tissues and describe markers that highlight the heterogeneity of these chameleons.

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Figures

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Insights from Lewis L. Lanier.
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Plasticity of ILC precursors and differentiation into ILC2 and ILC3. Nagasawa, et al. (2019) identify four subsets of human ILC precursor or progenitor cells based on expression of KLRG1 and NKp46, highlight discriminating transcription factors in the populations, and demonstrate their plasticity when stimulated with DL1 and polarizing cytokine environments.
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References

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